UC to J-Pouch Story

Will I give my child Colitis?

Posted by Megan on June 23, 2008

Ohhh, this is excellent. How many of you have asked or been concerned if you were going to pass your IBD genes on to your child, you can listen to this radio webcast here, Genetic Research on Colitis.   “20 percent of people with colitis have a close relative with ulcerative colitis or Crohn’s disease.”  Click Video here.

Here are excerpts from the transcripts Will I give my child Colitis genetically?

 
“Rick:
Right. And hopefully avoid a lot of that trial and error process of treating it. Now, when was colitis first perceived to be a genetic disorder, Dr. Walters?

Dr. Walters:
That’s a good question, Rick, and it’s very interesting. If you speak to people who have been in the area for many years, they can often show you the slides of the talks they gave maybe 20 years ago which might have said, While we don’t know what causes it, we know it’s certainly not due to your genes. And then we started doing more research. And what was the research? The research was to try to understand why we got the disease, and it comes down to very sort of simple research called epidemiology. Epidemiology is all about studying who gets what, where and when.

Rick:
Yes.

Dr. Walters:
And it doesn’t sound like rocket science, but, you know, it’s the way that we understood genes. Because what did we discover? We discovered that if you had IBD the most likely thing we are going to know about you is that someone else in your family had IBD as well. And that was the first hint. We then started looking at twins thinking, well, if this really is something to do with your genes, then surely identical twins would have it more often. And what do you know? When we looked, identical twins had it much more often than nonidentical twins. And that was really the turning point.

The next huge turning point was when we suddenly were able to look directly at genes. Now, no one would have bothered spending the money if we hadn’t done the simple research first that said it’s going to be in the genes. We started looking, and in the early ‘90s we started getting genetic results saying, you know, you are right. There are differences in people’s genes which seem to occur in people with IBD compared to people without IBD. And that really is from about the early to mid 1990s”

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